About Us

About Us

Company Overview

Prescient Therapeutics (ASX:PTX) is a clinical-stage biotech company  developing personalised medicine approaches to cancer, including targeted and cellular therapies.  Prescient’s technologies emanate from prestigious world class centres including Yale, Penn, Oxford and Moffitt.

Targeted therapies

Prescient’s two first-in class targeted therapies – PTX-100 and PTX-200 – are currently in clinical development and showing encouraging activity in diseases of unmet need.

Cell therapies

Prescient owns the exclusive rights to two next-generation cell therapy platform technologies, OmniCAR and CellPryme – both with the potential to enhance CAR-T therapies and overcome challenges faced by current generation approaches

Prescient works tirelessly alongside our world-class collaborators to develop truly differentiated therapies that have the capacity to help cancer patients live longer, better quality lives.

Our Team

Steven Yatomi-Clarke

CEO and Managing Director

Steven took over as CEO of Prescient Therapeutics in 2016 and has overseen its progression from start-up phase. Steven manages a team in Australia and the US and has been instrumental in strategy development; licensing; initiating and managing clinical trials; fundraising and business development.
Previously, Steven had a distinguished career as an investment banker specialising in the life sciences sector, where he was consistently one of the country’s most prolific bankers, involved in primary and secondary offerings, corporate advisory and M&A assignments. In particular, Steven leveraged his combined backgrounds in science and finance to identify undervalued and unlikely opportunities and structure deals for the mutual benefit of companies and investors.
Steven holds a Bachelor of Science with an Honours Degree in Biochemistry and Molecular Biology, and a Bachelor Commerce majoring in Economics, both from the University of Melbourne. He has been a collaborator on various immunotherapy research projects.

Steve Engle

Non-Executive Chairman

Steven Engle is CEO of CohBar, a clinical stage biotechnology company focused on the development of mitochondrial based therapeutics, an emerging class of drugs for the treatment of age-related diseases and extending healthy lifespan. Previously, he was CEO of Averigon, an advisory firm to the life science industry. Prior to that, he was Chairman and CEO of XOMA, a developer of antibody therapeutics of multiple diseases, and Chairman and CEO of La Jolla Pharmaceutical Company, which discovered the biology of B cell tolerance, developed the first B cell toleragen for lupus patients, and received an approvable letter from the FDA.
Mr. Engle served as VP of Marketing for Cygnus, a drug delivery company, where he helped gain FDA approval of and launch Nicotrol for smoking cessation. Mr. Engle is a member of the board of AROA, a developer and marketer of regenerative products, and of Author-it Software Corporation, a developer of authoring information solutions for pharmaceutical and biotechnology companies. He is a former director of industry associations, BIO, BayBio and BIOCOM.
Mr. Engle holds M.S.E.E. and B.S.E.E. degrees from the University of Texas with a focus in biomedical engineering.

Dr James Campbell

Non-Executive Director

Dr James Campbell brings to Prescient a solid track record as a scientist and commercial executive. Dr. Campbell has more than 20 years of international biotechnology research, management and leadership experience and has been involved in the creation and/or transformation of multiple successful Australian and international biotechnology companies.
He is currently CEO of Patrys Limited, a company developing novel antibody therapeutics for oncology.
He was previously the Chief Financial Officer and Chief Operating Officer of Chemgenex, which was acquired by Cephalon for $230 million in 2011. His responsibilities ranged from IP management to licensing and business development and as a member of the executive team, he helped steer and transform the company from a $10 million research based entity to a company with completed clinical trials and regulatory dossiers submitted to the FDA and EMA before its $230 million sale.
Dr Campbell also has experience advising private biotechnology companies in the US and New Zealand with capital raisings and partnering negotiations.

Dr Allen Ebens

Non-Executive Director

Allen Ebens, Ph.D. brings over twenty four years of drug development experience in oncology and hematology, beginning in drug discovery at Exelixis before moving to Genentech where over 11 years he worked from concept to clinic across multiple therapeutic platforms including antibodies, small molecule drugs, antibody-drug conjugates, and T cell recruiting antibodies.
Dr. Ebens was recruited from Genentech to establish oncology discovery research at Juno Therapeutics (a CAR-T pioneer), and served as Senior Director, Immune Oncology at NGM Biopharmaceuticals.
He is currently Chief Scientific Officer of Vera Therapeutics. Dr. Ebens’ scientific contributions include numerous peer-reviewed publications of original research, a significant patent portfolio, and the advancement of nine discovery projects from initial concept to clinical development for multiple targets including one marketed therapeutic. He completed his PhD at UCLA and postdoctoral training at UCSF.

Melanie Leydin

Chief Financial Officer and Company Secretary

Melanie Leydin is a highly experienced CFO and Company Secretary with 25 years of experience in the accounting profession and 15 years of experience in company secretarial services

Dr Ellen Feigal

Non- Executive Director

Dr Feigal is currently a Partner and Head of the Biologics practice at global life sciences advisory firm, NDA Partners LLC, where she leads efforts in designing and executing product development and regulatory strategies in the areas of cell therapies, medical imaging, hematology and oncology. She is also adjunct faculty at the Sandra Day O’Connor College of Law, Arizona State University, where she teaches FDA drug law and medical research ethics and law.

Dr Feigal was formerly Senior Vice President overseeing research and development with the California Institute of Regenerative Medicine, a world-leading research foundation working to accelerate development of new disease modifying treatments and cures for patients with chronic diseases; Executive Medical Director, Global Development at US biotech company Amgen Inc (NASDAQ: AMGN); Vice President of Clinical Sciences at the Translational Genomics Research Institute, and directed the Division of Cancer Treatment and Diagnosis at the National Cancer Institute.

Dr Feigal serves as a Board member for Xencor Inc (NASDAQ: XNCR) a biotechnology company developing engineered antibodies and cytokines for the treatment of cancer and autoimmune diseases. She is also a Director of NextCure (NASDAQ: NXTC) a clinical-stage biotechnology company developing new immunotherapies to treat cancer.

Dr Feigal holds an M.D. from the University of California, Davis School of Medicine. She completed an internal medicine residency at Stanford University and a hematology oncology fellowship at the University of California, San Francisco.

Steven Yatomi-Clarke

CEO and Managing Director

Steven took over as CEO of Prescient Therapeutics in 2016 and has overseen its progression from start-up phase. Steven manages a team in Australia and the US and has been instrumental in strategy development; licensing; initiating and managing clinical trials; fundraising and business development.
Previously, Steven had a distinguished career as an investment banker specialising in the life sciences sector, where he was consistently one of the country’s most prolific bankers, involved in primary and secondary offerings, corporate advisory and M&A assignments. In particular, Steven leveraged his combined backgrounds in science and finance to identify undervalued and unlikely opportunities and structure deals for the mutual benefit of companies and investors.
Steven holds a Bachelor of Science with an Honours Degree in Biochemistry and Molecular Biology, and a Bachelor Commerce majoring in Economics, both from the University of Melbourne. He has been a collaborator on various immunotherapy research projects.

Steve Engle

Non-Executive Chairman

Steven Engle is CEO of CohBar, a clinical stage biotechnology company focused on the development of mitochondrial based therapeutics, an emerging class of drugs for the treatment of age-related diseases and extending healthy lifespan. Previously, he was CEO of Averigon, an advisory firm to the life science industry. Prior to that, he was Chairman and CEO of XOMA, a developer of antibody therapeutics of multiple diseases, and Chairman and CEO of La Jolla Pharmaceutical Company, which discovered the biology of B cell tolerance, developed the first B cell toleragen for lupus patients, and received an approvable letter from the FDA.
Mr. Engle served as VP of Marketing for Cygnus, a drug delivery company, where he helped gain FDA approval of and launch Nicotrol for smoking cessation. Mr. Engle is a member of the board of AROA, a developer and marketer of regenerative products, and of Author-it Software Corporation, a developer of authoring information solutions for pharmaceutical and biotechnology companies. He is a former director of industry associations, BIO, BayBio and BIOCOM.
Mr. Engle holds M.S.E.E. and B.S.E.E. degrees from the University of Texas with a focus in biomedical engineering.

Dr James Campbell

Non-Executive Director

Dr James Campbell brings to Prescient a solid track record as a scientist and commercial executive. Dr. Campbell has more than 20 years of international biotechnology research, management and leadership experience and has been involved in the creation and/or transformation of multiple successful Australian and international biotechnology companies.
He is currently CEO of Patrys Limited, a company developing novel antibody therapeutics for oncology.
He was previously the Chief Financial Officer and Chief Operating Officer of Chemgenex, which was acquired by Cephalon for $230 million in 2011. His responsibilities ranged from IP management to licensing and business development and as a member of the executive team, he helped steer and transform the company from a $10 million research based entity to a company with completed clinical trials and regulatory dossiers submitted to the FDA and EMA before its $230 million sale.
Dr Campbell also has experience advising private biotechnology companies in the US and New Zealand with capital raisings and partnering negotiations.

Dr Allen Ebens

Non-Executive Director

Allen Ebens, Ph.D. brings over twenty four years of drug development experience in oncology and hematology, beginning in drug discovery at Exelixis before moving to Genentech where over 11 years he worked from concept to clinic across multiple therapeutic platforms including antibodies, small molecule drugs, antibody-drug conjugates, and T cell recruiting antibodies.
Dr. Ebens was recruited from Genentech to establish oncology discovery research at Juno Therapeutics (a CAR-T pioneer), and served as Senior Director, Immune Oncology at NGM Biopharmaceuticals.
He is currently Chief Scientific Officer of Vera Therapeutics. Dr. Ebens’ scientific contributions include numerous peer-reviewed publications of original research, a significant patent portfolio, and the advancement of nine discovery projects from initial concept to clinical development for multiple targets including one marketed therapeutic. He completed his PhD at UCLA and postdoctoral training at UCSF.

Melanie Leydin

Chief Financial Officer and Company Secretary

Melanie Leydin is a highly experienced CFO and Company Secretary with 25 years of experience in the accounting profession and 15 years of experience in company secretarial services

Dr Ellen Feigal

Non- Executive Director

Dr Feigal is currently a Partner and Head of the Biologics practice at global life sciences advisory firm, NDA Partners LLC, where she leads efforts in designing and executing product development and regulatory strategies in the areas of cell therapies, medical imaging, hematology and oncology. She is also adjunct faculty at the Sandra Day O’Connor College of Law, Arizona State University, where she teaches FDA drug law and medical research ethics and law.

Dr Feigal was formerly Senior Vice President overseeing research and development with the California Institute of Regenerative Medicine, a world-leading research foundation working to accelerate development of new disease modifying treatments and cures for patients with chronic diseases; Executive Medical Director, Global Development at US biotech company Amgen Inc (NASDAQ: AMGN); Vice President of Clinical Sciences at the Translational Genomics Research Institute, and directed the Division of Cancer Treatment and Diagnosis at the National Cancer Institute.

Dr Feigal serves as a Board member for Xencor Inc (NASDAQ: XNCR) a biotechnology company developing engineered antibodies and cytokines for the treatment of cancer and autoimmune diseases. She is also a Director of NextCure (NASDAQ: NXTC) a clinical-stage biotechnology company developing new immunotherapies to treat cancer.

Dr Feigal holds an M.D. from the University of California, Davis School of Medicine. She completed an internal medicine residency at Stanford University and a hematology oncology fellowship at the University of California, San Francisco.

Said Sebti, PhD

Scientific Founder
  • Co-inventor of PTX-100 & PTX-200
  • Named among top 20 Translational Researchers in the world by Nature Publishing Group

Terry Chew, M.D.

Chief Medical Officer
  • Hematologist/oncologist with 20 years experience in biotech & pharma
  • 5 New Drug Applications including DaunoXome, Taxotere and DepoCyte
  • PTX is only 1 of only 2 ASX biotechs with a CMO that has successfully approved drugs

Rebecca Lim, PhD

Senior VP – Scientific Affairs
  • Over 10 years of experience in allogeneic cell therapies for regenerative medicine
  • Initiated several first-in-human clinical trials for urgent unmet medical needs based on her research in cell therapies
  • Previously the Scientific Director for the Cell Therapies Platform at the Hudson Institute and an Associate Professor at Monash University
  • Crucial role in the tech transfer, product development and clinical delivery of Malaysia’s first CD19-targeted CAR-T trial.
  • Helped develop the RoteaTM Counterflow Centrifugal System for automated CAR-T manufacturing, now sold by Thermo Fisher Scientific

Daniel A. Shelly, PhD, MBA

VP – Business Development & Alliances
  • 20 years of business development experience focused on advanced biologics, vaccines, recombinant proteins, cell and gene therapies
  • Formerly at PATH; Albumedix/Novozymes Biopharma and Meridian Life Science
  • Adjunct Professor of Biologics Drug Development at the Uni of Cincinnati College of Pharmacy

Leanne West

Director of Clinical Affairs and Operations
  • Over 25 years of clinical experience in biotech, pharma and CROs
  • Extensive understanding of drug development, regulatory and clinical operations
  • Managed pre-clinical and Phase I-IV clinical programs in APAC, UK/Europe and North America.

Mike Preigh, PhD

VP – CMC
  • Led CMC at Array BioPharma for 10 years
  • Successfully brought >20 drug candidates to IND & clinical development
  • Previously Pfizer

Evan Siegel

Regulatory Affairs

Founder of regulatory affairs specialist Ground Zero Pharmaceuticals, Inc; has extensive regulatory experience including as a former toxicology reviewer at the US Food and Drug Administration

Said Sebti, PhD

Scientific Founder
  • Co-inventor of PTX-100 & PTX-200
  • Named among top 20 Translational Researchers in the world by Nature Publishing Group

Terry Chew, M.D.

Chief Medical Officer
  • Hematologist/oncologist with 20 years experience in biotech & pharma
  • 5 New Drug Applications including DaunoXome, Taxotere and DepoCyte
  • PTX is only 1 of only 2 ASX biotechs with a CMO that has successfully approved drugs

Rebecca Lim, PhD

Senior VP – Scientific Affairs
  • Over 10 years of experience in allogeneic cell therapies for regenerative medicine
  • Initiated several first-in-human clinical trials for urgent unmet medical needs based on her research in cell therapies
  • Previously the Scientific Director for the Cell Therapies Platform at the Hudson Institute and an Associate Professor at Monash University
  • Crucial role in the tech transfer, product development and clinical delivery of Malaysia’s first CD19-targeted CAR-T trial.
  • Helped develop the RoteaTM Counterflow Centrifugal System for automated CAR-T manufacturing, now sold by Thermo Fisher Scientific

Daniel A. Shelly, PhD, MBA

VP – Business Development & Alliances
  • 20 years of business development experience focused on advanced biologics, vaccines, recombinant proteins, cell and gene therapies
  • Formerly at PATH; Albumedix/Novozymes Biopharma and Meridian Life Science
  • Adjunct Professor of Biologics Drug Development at the Uni of Cincinnati College of Pharmacy

Leanne West

Director of Clinical Affairs and Operations
  • Over 25 years of clinical experience in biotech, pharma and CROs
  • Extensive understanding of drug development, regulatory and clinical operations
  • Managed pre-clinical and Phase I-IV clinical programs in APAC, UK/Europe and North America.

Mike Preigh, PhD

VP – CMC
  • Led CMC at Array BioPharma for 10 years
  • Successfully brought >20 drug candidates to IND & clinical development
  • Previously Pfizer

Evan Siegel

Regulatory Affairs

Founder of regulatory affairs specialist Ground Zero Pharmaceuticals, Inc; has extensive regulatory experience including as a former toxicology reviewer at the US Food and Drug Administration

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