About Prescient Therapeutics
Prescient’s universal CAR-T and targeted therapies are both personalised medicine approaches that seek to improve patient outcomes and provide new tools for clinicians in combating cancer.
Prescient receives new US Patent for Companion
Prescient Therapeutics (ASX: PTX) is pleased to announce that it has received a notice of allowance from the United States Patent and Trademark Office (USPTO) for a new patent covering methods for using a specific biomarker to stratify breast cancer patients and identify those most likely to respond to treatment with its anti-cancer compound PTX-100 (continue reading…)
CAR-T is a cell therapy which works by genetically modifying a patient’s own T-cells by adding a new receptor (CAR) to recognise cancer antigens. CAR-T therapy has achieved stunning success in certain blood cancers. However, conventional CAR-T also faces considerable challenges that limit their broader use, including manufacturing, safety and adaptability. The OmniCAR platform seeks to overcome these challenges. OmniCAR is a modular, universal CAR platform using technology exclusively from CAR-T pioneer the University of Pennsylvania (UPenn), as well as Oxford University. It has the potential to dramatically enhance the safety and efficacy of any CAR-T therapy, enabling in-house development of next-generation CAR-T therapies, and by dramatically improving external CAR-T programs it will create opportunities for collaboration and business development in the CAR-T field.
PTX - 100
PTX-100 is a first in class compound with the ability to block an important cancer growth enzyme known as geranylgeranyl transferase-1 (GGT-1), thereby disrupting the oncogenic Ras pathway. PTX-100 is currently in a novel basket Phase 1b study of cancers driven by Rho and Ras mutations.
PTX - 200
PTX-200 is a novel PH domain inhibitor that inhibits an important tumor survival pathway known Akt, which plays a key role in the development of many cancers, including leukemia; breast cancer and ovarian cancer.
Prescient Therapeutics has a broad pipeline of personalised cancer treatments, comprising CAR-T and targeted therapies, and spanning a range of different cancers. We have licensed technologies from, and also collaborates with, world-leading cancer centres in the United States as well as Australia.
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